The pair limped off in the latter stages of Sunday’s defeat by Ireland with ankle and knee injuries respectively and are returning to their clubs for treatment.
Edinburgh fly-half Charlie Savala was called up to the squad, while Josh Bayliss was back in the squad after being released to play Bath at the weekend.
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It remains to be seen if Ritchie Gray will be fit for this weekend’s fixture at PT Murrayfield. The 33-year-old lock was shut down after just six minutes on Sunday with suspected rib damage. He remained with the squad for the time being, raising hopes that he might be available to face Italy.
A statement from Scotland Rugby on Monday read: “Stuart Hogg has sustained an ankle injury and will not be available for the weekend match against Italy. He will return to his club in time to further manage this injury.
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“Vin Russell has suffered a ligament injury in his knee. He will be returning to Racing 92 to continue his rehabilitation.
Richie Gray sustained an injury during the Ireland game and will remain with the team to be assessed by doctors.
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